The purpose of this in vivo retrospective study was to evaluate the accuracy of a computer-designed stereolithographic surgical guide. One hundred eleven implants were placed in 10 patients. Pre- and postoperative computed tomography images were compared using specific software. Global, angular, depth, and lateral deviations were calculated between planned and placed implants. Mean global deviations between planned and placed implants at the coronal and apical aspects were 1.52 mm (range, 0.13 to 3.00 mm) and 1.97 mm (range, 0.34 to 4.23 mm), respectively, while the mean angular deviation was 4.68 degrees (range, 0.10 to 15.25 degrees). This study highlighted a reasonable mean accuracy with relatively high maximum deviations between the postoperative position and the preoperative plan. These results should serve as a warning for the clinician if implants are placed near vital structures.