DOI: 10.3290/j.ohpd.a9764Seiten: 369-376, Sprache: EnglischLang, Niklaus P./Anton, Elena/Gabriel, Yvonne/Pjetursson, Bjarni E./Winston, Leslie J./He, Tao
A double blind, controlled, parallel group trial utilizing the experimental gingivitis model was performed on thirty young adults to evaluate the clinical effects of a 0.45% stannous fluoride dentifrice used as a slurry on dental biofilm formation and the development of gingivitis.
Following a thorough examination and oral prophylaxis procedures, subjects were randomly assigned to apply one of the following dentifrices twice daily over a three-week period: A) dentifrice slurry without active ingredients; B) 0.45% stannous fluoride gel; and C) Colgate® Total dentifrice slurry (0.30% triclosan, 0.24% sodium fluoride, 2% copolymer).
After three weeks, the stannous fluoride dentifrice significantly (p < 0.05) reduced gingivitis compared with the Colgate® Total group by 39.7%. Gingival bleeding was also reduced relative to the Colgate® Total group. This difference was statistically significant (P < 0.05). During the experimental period, the mean PlI scores increased almost linearly in all three groups without yielding any statistically significant differences.
The results of this clinical trial demonstrated that, over a three-week period, the application of a 0.45% SnF2 gel significantly inhibited the onset of gingivitis compared to Triclosan/sodium fluoride/copolymer (Colgate® Total). However, neither stannous fluoride nor Triclosan/sodium fluoride/copolymer (Colgate® Total) possessed sufficient antimicrobial activity to suppress biofilm formation in the absence of regular oral hygiene practices.
Schlagwörter: prevention, gingivitis, stannous fluoride, dentifrice, plaque, discolorations