If a prosthetically guided implant rehabilitation is to be carried out, the patient must have adequate bone volumes; as a result of bone resorption in the alveolar process, the latter are not always present. An effective technique in regenerative surgery involves the use of titanium mesh to recreate the missing bone volume. New generation meshes have been used in this study: they present a new texture with micro holes and they can have a space-creating effect and a barrier effect. The primary objective of the study is to measure the height and width of the regenerated bone following the use of a new generation customized titanium mesh. This retrospective case series involved 18 patients, with a total of 23 bone atrophies who have undergone bone regeneration surgery with titanium mesh and subsequently implants have been placed. We achieved a vertical gain of 5.1 ± 2.9 mm and a medium horizontal gain is 12.3 ± 2.6 mm, with an average volume obtained during regeneration is 3.2 ± 1.3 cm3; we report one failure (4.3%) and in 3 cases (13%) it was necessary to perform a second minor surgery. The mean follow-up of implants after loading was 22.3 ± 15.6 months. This study showed the innovation of new generation titanium mesh, with a micro-perforated texture that offers both a spacemaking effect and a partial barrier effect. This has led to excellent results in terms of regeneration, with a significant improvement in vertical and horizontal defects treated and reduction in operating time. Future studies with longer follow-up will be necessary.