Open Access Online OnlyOral MedicineDOI: 10.3290/j.ohpd.b4528813, PubMed-ID: 3786130920. Okt. 2023,Seiten: 339-346, Sprache: EnglischHoshino, Takashi / Kaneko, Noboru / Yoshihara, Akihiro / Iwasaki, Masanori / Suwama, Kana / Ito, Yumi / Tanaka, Junta / Narita, Ichiei / Ogawa, HiroshiPurpose: To investigate the association between plasma antibody levels against Porphyromonas gingivalis (PG) and atrial fibrillation (AF) history in community-dwelling older individuals in Japan.
Materials and Methods: This study was a subset of the Uonuma cohort study, including 3091 participants aged 60–79 years. Data were collected, including AF history as a dependent variable, plasma immunoglobulin G antibody levels against PG as an independent variable, and previously reported AF risk factors and demographic information as covariates.
Results: The median age of the participants was 69 years. Of the 3091 participants, 1411 (45.6%) were men, and 56 (1.8%) had an AF history. AF prevalence was significantly higher in participants with higher antibody levels against PG than in those with lower antibody levels (3.0% vs 1.4%; p = 0.005). Multivariable logistic regression analysis showed that participants with higher antibody levels against PG had twofold higher odds of having AF (odds ratio = 2.13; 95% confidence interval = 1.23–3.69). Restricted cubic spline analysis indicated a nonlinear relationship between antibody levels against PG and AF history.
Conclusion: Plasma antibody levels against PG were associated with AF history in community-dwelling older individuals in Japan.
Schlagwörter: antibody level, atrial fibrilation, older adults, periodontitis, Porphyromonas gingivalis, older adults