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Prof. Dr. Luc W. M. van der Sluis

Netherlands
Prof. dr. L.W.M. (LUC) van der Sluis graduated in 1985, completed the postgraduate endodontic program in 1993 under guidance of prof. dr. P.R. Wesselink and received his PhD degree in 2007 under supervision of prof. dr. P.R. Wesselink and dr. M-K. Wu at ACTA, the Netherlands. Since 1993 Luc worked in a practice limited to Endodontics and held a position in research and teaching until 2010 at the Department of Cariology, Endodontology and Pedodontology at ACTA. From 2010 until 2012, Luc worked as professor at the University of Toulouse (France). Actually Luc is head of the Center for Dentistry and Oral Health at the University Medical Center of Groningen in the Netherlands and researcher at the Kolff Institute (University of Groningen). The current focus of his research is the prevention of apical periodontitis, disinfection of the carious lesion and root canal system, which he systematically investigates with specialists in biofilm research, fluid dynamics and (sono) chemistry.

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This author's journal articles

  
ENDO, 3/2007
Pages 173-180, Language: EnglishÖzok, Ahmet R. / van der Sluis, Luc W. M. / Wu, Min-Kai / Wesselink, Paul R.

Biofilm in relation to root canal infection

Microbial biofilms are clusters of microorganisms immobilised on a surface or an interface, enveloped in a slimy matrix of their own creation. In infected root canals, microbial biofilms are formed on hard tissue surfaces of the root canal system. Infection of the root canal system is the cause of apical periodontitis, and complete elimination of the infection is the ultimate goal of root canal treatment. However, this aim is quite difficult, if not impossible, to achieve, due to not only the complexity of the root canal system, which offers inaccessible niches for microorganisms, but also the fact that there are protective advantages in residing in biofilms. Microorganisms in biofilms are more resistant to antimicrobial regimes than their counterparts in planktonic form. A good understanding of the distinctive features of a microbial biofilm, particularly in root canal infection, is important to enable development of techniques to eliminate the microbial biofilm, and as a result, (post-treatment) apical periodontitis. In the following review, the definition, main features and significance of a microbial biofilm, and its relevance to root canal infection will be discussed. Keywords: biofilm, endodontic, root canal infection
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