This case report demonstrates the use of dynamic navigation guidance for bone reduction. Information about smile line position incorporated in a virtual plan and accurate transfer to the surgical field enhances the predictability of the treatment. A virtual wax-up was made, and implant positions along with bone reduction were planned accordingly. Residual teeth in the maxilla were extracted, and bone reduction and zygomatic implant placement were assisted by surgical navigation, while conventional implants were placed using the surgical template, followed by immediate loading. When surgical navigation is used for implant placement, navigated bone reduction can easily be incorporated in the workflow. The accuracy of bone reduction was evaluated together with the accuracy of two zygomatic implants assisted by a navigation system and four conventional implants assisted by a static template. The mean deviation between planned and performed bone reduction was 1.3 ± 0.39 mm (range: 0.8 to 1.7 mm). The accuracy of this procedure corresponds to the accuracy of guided implant placement and can be considered reliable after confirmation through clinical trials.