A 79-year-old female patient wearing a 10-year-old implant fixed restoration presented with an increasing bone loss caused by a progressive peri-implantitis, and she requested a new implant fixed prosthesis because she was not able to get a conventional prostheses attached in her the edentulous mandible. The basic situation was marked by a major 3D bone defect in area 35 to 45. The inflammation and the occurred explantation left quite an ungentle and scar-penetrated soft tissue. Based on a DVT diagnostic, a customized YxossCBR^® titanium scaffoldwas constructed and the surgery performed (1. augmentation; 2. Implantation). Following the prosthetics were designed and incorporated (time interval in total of 9 months). The case aims to demonstrate a possible solution to move from a severe peri-implantitis to a complete restoration of the intraforaminal area using a new implant loaded prosthesis fixed in an edentulous mandible, under ambulant conditions. In addition, we will show an in house statistic about 27 implanted Yxoss meshes, including also failures and complications. Keywords: peri-implantitis, re-implantation, yxoss, bio oss