The aim of this study was to quantify the strain development of screw-retained three-unit implant-supported Procera Implant Bridge restorations. Two groups of screw-retained implant-supported restorations (n = 10) were fabricated by means of casting or computer-aided design/computer-assisted manufacture (CAD/CAM) to fit an in vitro cast situation with two implants. During fixation of the restorations, the emerging strains were recorded using strain gauges attached to the cast material mesially and distally adjacent to the implants. Absolute mean strain development ranged from 29.35 µm/m to 2,665.80 µm/m at the different strain gauge locations. Fabrication method had a significant effect on strain development (multivariate analysis of variance, P = .000), with the cast restorations showing significantly higher strain levels compared to the CAD/CAM-fabricated superstructures. CAD/CAM fabrication of screw-retained implant-supported restorations provides greater passivity of fit compared to conventional fabrication methods such as casting.