Purpose: The aim was to assess the influence of connection of the canine teeth to implant-retained long-span fixed dentures on stress in mandibular bone using finite element analysis. Materials and Methods: Each 3-dimensional model included bone, 6 implants, both natural canines, and superstructures. Each model simulated 1 of 4 prosthetic designs: a tooth/implant-retained 1-piece superstructure (One-piece), 3-piece superstructures with an anterior and 2 posterior segments with unconnected teeth (UnConnect), 3-piece superstructures with the teeth connected to the posterior segments (PostConnect), and 3-piece superstructures with the teeth connected to the anterior segment (AntConnect). A nonlinear elastic modulus was applied to the periodontal ligament (PDL). Maximum intercuspal (IP), canine-protected (CP), and group-function (GF) occlusions were simulated. Results: The maximum stresses in the peri-implant regions of the bone were lower for the One-piece than for the other superstructures. In PostConnect and AntConnect, the maximum stress in the PDL was lower than that in UnConnect, but the stress in the peri-implant bone was comparable in those 3 models. The stresses were lower in the GF model than in the CP model. The stress created in the peri-implant bone was insensitive to the modes of the teeth/implant connection in long-span fixed dentures. Conclusion: Within the limitation of the mechanical analysis, it is suggested that the connection of the canine tooth to the implant-retained long-span superstructures is an acceptable option in partially edentulous patients. Keywords: dental implants, finite element analysis, periodontal ligament, tooth-implant support