Objectives: This research aims to confirm the association between dyslipidemia, oral health behaviors, and periodontal disease according to age groups. Method and materials: This cross-sectional study used collected data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted from 2012 to 2015 with 17,004 adults. Complex samples logistic regression analysis confirmed the relevant factors of oral disease. Results: Hypo high-density lipoprotein cholesterol (HDL-C) related to periodontal disease in two groups (under 40 and over 40 years old). In the over-40 age group, the level of low-density lipoprotein cholesterol (LDL-C) was associated with periodontal disease; toothbrushing frequency and usage of interdental hygiene products were associated with periodontal disease. Conclusions: Better HDL-C level in all age groups, management of LDL-C level, tooth-brushing at least twice a day, and additional use of interdental hygiene products in the over-40 age group were associated with better oral health. Thus, public and oral health professionals should emphasize the relationship according to age group during health care education and share relevant information. Keywords: dyslipidemia, KNHANES, oral health behavior, periodontitis, tooth brushing