Association of MMP-8 rs11225395 Polymorphism with the Susceptibility of Peri-Implantitis

Purpose: Peri-implantitis (PI) is the primary cause of implant failure, and genetic susceptibility significantly influences its development. This study investigated the association between the MMP-8 rs11225395 polymorphism and PI in the Chinese Han population.
Materials and Methods: In this study, 140 Chinese Han patients diagnosed with PI and 156 healthy implant controls were included. Polymerase chain reaction (PCR) was employed to detect the MMP-8 rs11225395 polymorphism, and the Hardy–Weinberg equilibrium test was conducted to assess the representativeness of the samples. Additionally, enzyme-linked immunosorbent assay (ELISA) was utilised to quantify the expression levels of MMP-8, and logistic regression analysis was performed to identify independent risk factors for PI disease.
Results: There were statistically significant differences in the genotype and allele distributions of the MMP-8 rs11225395 locus between PI patients and the control group. Rs11225395 T allele was significantly associated with an increased risk of PI, particularly for individuals with the TC/TT genotype who exhibited higher susceptibility to the disease. Periodontal status indicators differed markedly among PI patients with different genotypes. Factors such as plaque index, brushing daily, probing pocket depth (PPD), clinical attachment loss (CAL), and MMP-8 rs11225395 polymorphism played crucial roles in PI risk. Additionally, MMP-8 expressions were upregulated in PI patients. Specifically, at the rs11225395 locus, individuals with the TC/TT genotype showed a significantly higher relative expression level of MMP-8.
Conclusion: The MMP-8 rs11225395 polymorphism was significantly associated with genetic susceptibility to PI. Keywords: MMP-8, Rs11225395, polymorphism, peri-implantitis