Purpose: To compare the accuracy of milled versus 3D-printed complete denture bases and teeth and to assess the position of the teeth in relation to the corresponding denture bases. Materials and Methods: Two different manufacturing techniques were used in this study. In Group A, 10 complete dentures were digitally designed and fabricated by milling prepolymerized blocks of polymethyl methacrylate (PMMA). In Group B, 10 complete dentures were digitally designed and fabricated using a 3D-printing technique. The accuracy of the maxillary and mandibular denture bases and teeth and the positions of the teeth in relation to the corresponding denture bases were evaluated using Geomagic Control X software (Oqton). Data were presented as mean and SD values. Statistical analysis of the resultant data was performed using Student t test. The significance level was set at P ≤ .05. Results: With regard to denture bases, lower surface deviation values were found in the maxillary and mandibular milled denture bases (Group A), with values of 0.158 ± 0.024 and 0.117 ± 0.022, respectively. However, regarding the denture teeth, lower surface deviation values were found for printed teeth (Group B), with values of 0.18 ± 0.016 for the maxillary teeth and 0.153 ± 0.02 for the mandibular teeth. For positioning of the teeth in relation to the corresponding denture bases, the values were 0.4 ± 0.08 for the maxillary teeth and 1.003 ± 0.027 for the mandibular teeth. Conclusions: The milling technique yields complete denture bases with superior accuracy, whereas printing technology produces denture teeth with better accuracy and positioning in the corresponding denture bases.