The replacement of a single tooth can be achieved through multiple restorative alternatives. Resin-bonded fixed restorations are the most conservative option if dental implant placement is not possible or is contraindicated. Over the years, an increase in knowledge and the improvement of materials and technologies have enriched many aspects of this technique. According to the literature, single-retainer all-ceramic cantilevered restorations made either from zirconia or lithium disilicate have shown long-term success. The present article describes the updated, scientifically validated protocols of this technique with a particular focus on framework design and adhesive procedures, including a clinical report with a 6-year recall of maxillary lateral incisor agenesia that was managed with a single-retainer lithium disilicate fixed restoration.