Some of the critical clinical challenges encountered in the treatment of adult patients with deep overbite and worn dentition include correction of deep overbite, establishment of an appropriate occlusal vertical dimension (OVD), and maintenance of long-term occlusal stability. Although Angle’s Class II division 2-associated deep anterior overbite is common in orthodontic treatment, simple prosthodontic treatment with great improvement of deep anterior overbite and worn dentition is infrequently reported. A 51-year-old man with Class II Division 2 malocclusion presented with hypo-divergent facial pattern, reduced lower facial height, and protuberant lips. Intraoral examination revealed unevenly worn dentition and an Angle’s Class II division 2-associated deep and traumatic anterior overbite. Based on the challenges of the presentation, it was imperative to design an protocol to ensure a predictable and favorable prognosis. According to the current protocols, prosthetic treatment of occlusal rehabilitation was applied. Following the 3-month evaluation period using interim prostheses, full-mouth ceramic restorations were completed. Significant post-treatment functional and aesthetic improvements were achieved with resultant stable inter-incisal contacts either immediately after treatment or during the 2-year follow-up period. Full mouth rehabilitation offers brilliant prospects for improved function, enhanced aesthetics, and improved health of the entire stomatognathic system of Angle’s Class II division 2 patient associated with deep overbite and worn dentitions.