This study examined changes in facial geometry while playing wind instruments. Nine musicians (six men and three women, mean age 52 years) participated in part one of the study, and three musicians (three women, mean age 41 years) participated in part two. In part one, the high and low notes of each instrument were selected as test sounds. Facial geometry data were recorded using a 3D scanner. In part two, facial geometry data were recorded using a 4D scanner while a melody was played. Data were superimposed and analyzed using 3D analysis software. Numerical values and color maps of deviations were obtained. The results of part one revealed that the median 3D deviation was 1.1 mm (range 0.42 to 1.45 mm), indicating that facial geometry while playing high and low notes varied. The results of part two showed that the stable part was the frontal region and dorsal part of the nose. The approach used in this study has potential applications for evaluating facial geometry during musical instrument performances.