Some of the critical clinical challenges encountered in the treatment of adult patients with deep overbite and worn dentition include correction of deep overbite, establishment of an appropriate occlusal vertical dimension (OVD), and maintenance of long-term occlusal stability. Although Angle Class II, division 2–associated deep anterior overbite is common in orthodontic treatment, simple prosthodontic treatment with great improvement of deep anterior overbite and worn dentition is infrequently reported. A 51-year-old man with Class II, division 2 malocclusion presented with a hypodivergent facial pattern, reduced lower facial height, and protuberant lips. Intraoral examination revealed unevenly worn dentition and an Angle Class II, division 2–associated deep and traumatic anterior overbite. Based on the challenges of the presentation, it was imperative to design a protocol to ensure a predictable and favorable prognosis. According to the current protocols, prosthetic treatment of occlusal rehabilitation was applied. Following the 3-month evaluation period using interim prostheses, full-mouth ceramic restorations were completed. Significant posttreatment functional and esthetic improvements were achieved with resultant stable interincisal contacts either immediately after treatment or during the 2-year follow-up period. Full-mouth rehabilitation offers brilliant prospects for improved function, enhanced esthetics, and improved health of the entire stomatognathic system of an Angle Class II, division 2 patient associated with deep overbite and worn dentition.