Purpose: This 1-year prospective study evaluates the implementation of the AMETO register in the region of Southern Denmark and how data application relates to the following Institute of Medicine, World Health Organization, and Organisation for Economic Co-operation and Development health domains: Efficiency, Effectiveness, Patient Centered Care- , Timeliness, Safety, and Equitability. Materials and Methods: Implementation of the register was measured using patients registered by the age of 18 years. Inclusion criteria were access to the following data: type of treatment, one- or two-stage procedures, bone augmentation, implant characteristics, and suprastructure retention methods as optional measures of Efficiency; treatment outcome measures, implant survival, peri-implant bone level and health, suprastructure conditions, and cosmetic results as optional measures of Effectiveness; anamnestic information and Oral Health Impact Profile (OHIP)-5 questionnaires as optional measures of Patient Reported Outcome Measures Patient Centered Care; patient readiness for implant insertion by performed orthodontic pre-implant treatment as a measure of Timeliness; avoiding adverse effects of medication, allergic reactions, and tissue damage as optional measures of Safety; age, gender, ethnicity, geographic location, and socioeconomic data as optional measures of Equitability. Results: There were 227 registered patients. Twenty-six patients (25 with dental agenesis and one with trauma) were included, fulfilling the study’s power estimate that was calculated using peri-implant bone level at 1-year follow- up. Patients lacking OHIP questionnaires, implant information, or intraoral radiographs were excluded. Conclusions: Implementing the AMETO register was challenging. The clinical data in the AMETO register correlate well with the domains used by the IoM, WHO, and OECD.