Introduction: Tumor growth and progression goes hand in hand with a functionally vascularity. Till now the molecular basics are not fully understood. In this investigation the gene expression of ANGPT1 and ANGPT2 was analysed and correlated to each other. Further the gene expression and the ratio were compared to clinical parameters. Material and Method: The gene expression patterns of ANGPT1 and ANGPT2 from 83 OSCC samples were analysed. Data were correlated to each other and to clinical parameters. The statistical analysis was done with SPSS (version 22) Results: ANGPT1 and ANGPT2 showed a contrary gene expression. Relating to tumour size ANGPT1 is down regulated and ANGPT2 is up regulated. Relating to differentiation grade ANGPT1 is up regulated (p > 0.0001***) in G1 and down regulated in G2 and G3. The expression ratio of ANGPT1/ANGPT2 increases with tumour size (p > 0.007**) and differentiation grade (p > 10-8****). Conclusion: On the basis of our results, expression ratio of ANGPT1/ANGPT2 is a potential prognostic factor for tumour angiogenesis, growth, and aggressiveness. Keywords: gene expression, OSCC, angiopoetine