Objectives: Hypoallergenic-denture-base-materials [HDBM] are free from toxic or potential allergic substances. To clinically substitute conventional PMMA-denture-base-resins [PDBR] HDBM should meet the standards in mechanical-physical properties. Fundamental material properties are flexural strength [FS] and flexural modulus [FM]. High FS/FM-values contribute to the preservation of edentulous jaw areas. FS is an indicator of the strength and work capability in denture materials. A High FM value specifies rigidity as well as stiffness and represents denture base material's resistance to elastic deformation. The aim of this in-vitro study was to evaluate mechanical-physical properties of HDBMs and the comparison to established PDBRs. Methods: The 7 tested HDBMs (Acetal, Erkokryl, Luxene, Microbase, Polyan, Sinomer, Versio.com) were free from toxic or potential allergic substances. 3 PDBRs (Paladon65, PalaXpress, SR-Ivocap) represented the standard levels [SL-FS/SL-FM]. Specimens (60x10x4mm) were produced by the respective manufactures. 6 specimens from each product were tested in the three-point-bending-test according to ISO178:2006. The automatically recorded force measurement (TestXpert 8.1, Zwick, Germany) was performed until fracturing at a test speed of v=5mm/min. FS and FM were calculated and analyzed (T-test, p Keywords: flexural strength, flexural modulus, hypoallergic, denture base materials