Objective: The purpose of the study was histologic evaluation of healing process of the intraosseus defects in rabbits with or without using of GBR techniques after 6 months. Material and methods: This reserch was performed on 12 adult white rabbits. The rabbits were divided into three groups for the sake of the way of intaosseus defects treatment (I- control group, II- Bio-Oss Collagen + Bio-Gide Perio, III- Bio-Oss Collagen + PRP). Results and Conclusions: Usage of guide bone regeneration controlled after six months post augmentation caused increase of number of bone trabeculas in comparison with the control group. Biomaterial osteointegration process in second group was faster with less intensity of inflammatory reaction than in the third group, but in both cases this process was not finished. Keywords: intraosseus defects, healing process, guided bone regeneration, animal studies