The endodontic management of enamel mineralisation defects, such as amelogenesis imperfecta, may be challenging because the root canal configuration of affected teeth is often abnormal. This report of two cases illustrates the difficulties of cleaning, shaping and obturating the root canal system of teeth with amelogenesis imperfecta. Keywords: amelogenesis imperfecta, hypomineralisation, pulpal anomalies, root canal anatomy