The aim of this article was to report the presentation and management of a clinical case with neurological and facial skin complications secondary to the extrusion of sodium hypochlorite and calcium hydroxide into the facial soft tissues during root canal treatment. An adult male patient was referred to the endodontic clinic after inadvertent extrusion of sodium hypochlorite and calcium hydroxide into the periapical tissues during root canal treatment. The severe clinical consequences, with particular emphasis on nerve deficit and soft tissue are discussed and its management is highlighted. Early and aggressive treatment is advocated following such incidents in order to reduce potentially serious complications. This article demonstrates the possible detrimental effect of extrusion of sodium hypochlorite and calcium hydroxide intracanal dressing into the periradicular and adjacent soft tissues. Keywords: calcium hydroxide, irrigation, nerve damage, skin scarring, sodium hypochlorite