The purpose of this randomized clinical trial was to determine the clinical wear behavior of three nanofilled composites (Filtek Supreme XT [FS], Tetric EvoCeram [TEC], and Aelite Aesthetic [AA]) with two indirect composites (Estenia [E] and Tescera ATL [TATL]) on permanent molar teeth. Fifty-four patients whose treatment plans included moderate Class I and/or II restorations on molar teeth were selected for inclusion in this study. Wear was measured by use of gypsum replicas at baseline and 6 and 12 months using three-dimensional scanning and rapid-form software to elucidate the wear mechanisms. For statistical analyses, one-way analysis of variance and the Scheffé test were used. Statistical results revealed that wear behavior of TATL was significantly different from that of AA (P .05). No significant differences were detected between AA and E (P > .05) or between TEC, FS, and TATL composite resins (P > .05). The results showed similar clinical performance between the five composite resins evaluated. Therefore, composite resins may be indicated for the restoration of posterior teeth. However, the composition of the composite resin did affect the wear behavior of the composite material.