The present case report provides histologic findings on four titanium plasma-sprayed screw implants after 12 years of incorporation and functional load in a 95-year-old patient. At the time of implant placement, the four implants were immediately connected with a bar and functionally loaded with a bar-supported overdenture. The histologic analysis demonstrated excellent osseointegration in either cortical or cancellous bone for all implants. The histomorphometric analysis showed direct bone-implant contact of approximately 70% to 80% at the interface. Close to the implant surface, signs of ongoing bone remodeling activities were present. The present histologic case report confirms the validity of the applied treatment concept - to immediately load titanium implants with a titanium plasma-sprayed surface in the anterior region of the mandible - if a minimum of four implants can be inserted and if the four implants are splinted with a bar.