Purpose: The aim of this study was to clinically monitor the progression of tooth wear over a period of 1 year in a cohort of referred tooth wear patients through the use of a computer-aided design/ computer-assisted manufacture (CAD/CAM) scanner and a standardized scanning/assessment methodology. Materials and Methods: Polyether impressions were made of 11 participants (130 teeth) at baseline and at 1 year. Impressions were poured in type IV dental stone and the anterior teeth were 3D scanned. A surface-matching software was used to compare 1-year and baseline scans and identify any dimensional differences. Results: Parafunctional habits were reported by all patients. All participants exhibited tooth wear ≥ 140 μm in depth and extending to ≥ 280 μm in at least one tooth. Maxillary central incisors were the most commonly and severely affected teeth. Conclusion: The ability of the developed CAD/CAM scanning methodology in clinical monitoring of tooth wear was demonstrated. Further research is needed to assess its practicality in largescale epidemiologic tooth wear studies.