The purpose of this study was to compare the accuracy of casts made using three different impression techniques to obtain an accurate definitive cast for fabrication of multiple-implant prostheses. Twelve experimental groups were formed combining the following conditions: three impression techniques, two impression materials, and two cast materials. The main effects of the three factors were analyzed by three-way analysis of variance using the full factorial general linear model between factors. The results showed that there were no significant differences in mean values for the transferred dimensions between the control and experimental groups. None of the measurements in the horizontal plane of the definitive casts demonstrated significant differences among the impression techniques with different impression and cast materials (P > .01).