The objective of this study was to assess the change in oral health-related quality of life following treatment with double crown-retained removable partial dentures (RPDs). Sixty RPDs in 54 patients (mean age: 65 years) were fabricated and retained with either galvanoformed telescopic secondary crowns (n = 30) or conical secondary crowns (n = 30). The Oral Health Impact Profile (OHIP) was assessed pretreatment and during 6- and 12-month follow-up appointments. Patient assessment of denture-satisfaction was also recorded on a Lickert-type scale. A decrease in the OHIP-sum score was significant after treatment for both groups, but not between the experimental groups. The denture assessment showed good values for both groups. Treatment with different double crown-retained RPDs improved oral health-related quality of life.