Purpose: The aims of this study were to evaluate the in vitro shear bond strength of the dentin-titanium interface mediated by Fuji Plus, a resin-modified glass-ionomer cement, applied in combination with several self-etching bonding systems, and to compare the values obtained with those of SuperBond, chosen as a reference luting agent. Materials and Methods: The self-etching bonding systems used in combination with Fuji Plus were AdheSE, Xeno III, Clearfil SEBond, Unifil Bond, and an experimental self-etching bonding system comprising the sequential application of Xeno III and the bonding component of SE Bond. Two control groups were also tested: a negative control with Fuji Plus along with its conditioner (10% ferric chloride, 2% citric acid solution); and a positive control with the resin cement SuperBond. One hundred five human molars were used to prepare seven groups of fifteen samples each. The samples were tested in shear after 7-day storage at 100% relative humidity and 37°C. Results and Conclusion: Three of the tested combinations of self-etching bonding systems with Fuji Plus significantly improved in comparison with the negative control group, from 9% to 44%. The self-etching bonding systems obtained using Fuji Plus in combination with Clearfil SEBond, Unifil Bond, and the experimental system were not different from those obtained with SuperBond.