Recently, computer technology has made it possible to simulate implant placement, fabricate a precise surgical template based on the simulated implant locations, and fabricate a prosthesis prior to surgical placement of implants. Many successful patient treatments have been reported using this process, but little has been published regarding complications. This article reports on the misfit of an immediately loaded definitive fixed complete denture that had been fabricated prior to implant surgery. The prosthesis was designed and fabricated using computerized implant data. A surgical template was fabricated (Nobel Guide) from the computer data to guide implant placement using an "All-on-Four" design concept. Management of the prosthesis misfit is discussed along with subsequent clinical complications. Keywords: all-on-four, computer-guided surgery, dental implants, fixed complete denture, immediate loading, misfit, nobel guide