A 72-year-old patient underwent the placement of 2 screw-type implants. After 5 months the patient died of a massive stroke, and a block section of the portion of the mandible containing the implants was done. The specimen was treated to obtain thin ground sections. A 1- to 5-µm gap was present between the implant and the healing cover screw, and this space was filled by bacteria and calculus; bacteria were also present in the most apical portion of the hollow part of the implant. An inflammatory infiltrate was present in the connective peri-implant tissues. The spaces between all implant components (implant, abutment, and healing screw) can act as conduits and reservoirs for bacteria, which could cause inflammation of the peri-implant soft tissues. In conclusion, the histologic data from this autopsy case may help to confirm the penetration by fluids and bacteria into the internal portion of the implants, obtained from previous in vitro and in vivo studies. Keywords: bacterial penetration, peri-implantitis, 2-stage implants