Background: Numerous publications have reported on migraines misdiagnosed as endodontic pathologies. However, reports on the effect that concurrent migraine and endodontic pathology can have on each other and how their respective treatments can also affect each other are limited. Clinical Presentation: Two cases are reported that presented with both migraine and periapical pathology. Patient 1 underwent root canal treatment, which partially alleviated both the migraine and odontalgia. Subsequent treatment with sumatriptan provided additional relief. Patient 2 underwent sumatriptan treatment, with no effect. Subsequent root canal treatment provided significant relief. Patients in both cases have shown continued improvement. Conclusion: Further research is necessary, but the two cases presented suggest that endodontic pathology and migraine symptoms may be associated and endodontic therapy may have an effect on migraine pain. Keywords: case report/series, diagnostic procedure, endodontic diagnosis, headache, pain