The case of an 18-year-old woman with generalized short root anomaly (SRA) is presented, and the clinical management and challenges associated with this rare condition are discussed. The patient was referred for restoration of the edentulous maxillary left anterior region. Due to the SRA, the patient had previously received limited orthodontic treatment for the ectopic maxillary canines. The maxillary left canine failed during orthodontic traction, the left lateral incisor migrated in its region and had poor prognosis due to severe mobility. Therefore, it was extracted and the region was restored with an implant-supported cantilever metal-ceramic fixed partial denture. Radiographic examination revealed generalized SRA along with other dental anomalies. From the patient's family history, as well as from the physical, clinical, radiographic, biochemical, and histologic evaluations, we were unable to identify the etiology behind this unique combination of dental anomalies. Esthetics and function were successfully restored and a strict recall system was implemented in order to monitor and maintain the short-rooted teeth. The need to prevent tooth and periodontal tissue deterioration in patients with generalized short roots is emphasized. Keywords: dental syndrome, displaced canines, short root anomaly, taurodontia, third molar agenesis, transposition