Purpose: To evaluate four formulations of tetracalcium phosphate combined with phosphoserine (TTCP-PS) in comparison to the conventional grafting materials bioglass (BG) and deproteinized cancellous bovine bone with a bioresorbable collagen membrane in standardized defects created in the angle of the rat mandible. Materials and Methods: TTCP-PS is a synthetic, injectable, cohesive, self-setting, mineral-organic wet-field adhesive. Microcomputed tomography (microCT) and histomorphometry were used to evaluate bone replacement with each of these materials after in vivo residence of either 4 or 12 weeks. Results: Specific TTCP-PS formulations can form bone comparable to conventional materials in an osteopromotive mechanism but with the advantage of having cohesive and adhesive properties. Conclusions: This study showed the potential for TTCP-PS to be used as a viable candidate for bone grafting procedures.
Keywords: biocompatible biomaterials, bone adhesive, bone graft resorption, bone regeneration, bone-to-implant interface, calcium phosphate, cohesive bone graft, histomorphometry, injectable graft material, mineral-organic cement, mandibular defect model, microCT, osteopromotion, preclinical in vivo study, tetracalcium phosphate phosphoserine (TTCP-PS)
