In the update of the S3 guideline "All-ceramic single crowns and fixed dental prostheses" (AWMF Reg. No. 083-012) published in June 2021, new scientific evidence was incorporated into the guideline first published in 2014. The guideline established a broadly consented, evidence-based framework within which the use of tooth-supported all-ceramic restorations offers comparable long-term clinical outcomes to metal-based crowns and fixed dental prostheses (FDPs). In the updated version (version 2.0), all chapters have been reviewed with regard to new research findings, backgrounds have been newly discussed, and numerous recommendations have been updated with regard to indications and localization. In the process, the recommendation grading of individual materials was adjusted on the basis of new literature. Recommendations on materials that are no longer on the market (alumina ceramics) were removed and recommendations on new materials and applications were added (zirconium oxide ceramics [3Y-TZP] monolithic; zirconium oxide ceramics [4Y-, 5Y-TZP and combinations with these]; resin-matrix ceramics; lithium silicate/phosphate glass-ceramics). Recommendations on endocrowns were also made for the first time. In addition, the questions regarding the treatment of bruxism patients with all-ceramic restorations as well as material-specific manufacturing recommendations were re-evaluated. The main recommendations are listed in this article, the key innovations are emphasized, and the considerations of the guideline group in arriving at the recommendations are summarized. All recommendations as well as complete references can be found in the long version of the German S3 guideline. Keywords: all-ceramics, crowns, fixed dental prostheses, guideline, prosthodontics, restorative materials, survival rates