A 59-year-old woman was referred for specialist treatment due to peri-implantitis affecting four implants in the anterior maxilla. On presentation, probing depths were up to 12 mm with bleeding on probing/suppuration and extensive peri-implant bone loss. There was a history of treated chronic periodontitis. Nonsurgical management was followed by regenerative peri-implant surgery. Peri-implant probing depths reduced to a maximum of 5 mm and remained stable throughout the 5-year follow-up period. Cone beam computed tomography at 2 years postoperatively confirmed the presence of regenerated peri-implant tissue and integration with the pre-existing peri-implant bone.