Intracisternal and Intraperitoneal Administration of Morphine Attenuates Mechanical Allodynia Following Compression of the Trigeminal Ganglion in Rats

Aims: To investigate the effects of morphine on mechanical allodynia following compression of the trigeminal ganglion in the rat. Methods: Experiments were carried out on male Sprague-Dawley rats weighing between 250 and 260 g. For compression, a 4% agar solution (8 µL) was injected into the trigeminal ganglion. In the control group, rats were sham operated without agar injections. The authors evaluated the effects of intraperitoneal or intracisternal administration of morphine on mechanical allodynia evoked by air-puff stimulation of the vibrissa pad area 14 days following compression of the trigeminal ganglion. Results: Mechanical allodynia was established within 3 days and lasted beyond postoperative day 24. Intraperitoneal administration of morphine (2 or 5 mg/kg) significantly blocked mechanical allodynia ipsilateral to the compression of the trigeminal ganglion. Intraperitoneal administration of morphine also inhibited mechanical allodynia on the contralateral side. Moreover, intracisternal administration of morphine (5 µg) strongly suppressed both ipsilateral and contralateral mechanical allodynia. The antiallodynic effects of morphine were blocked by pretreatment with naloxone, an opioid receptor antagonist. Conclusion: These results suggest that the application of a high dose of morphine may be of great benefit in treating trigeminal neuralgia-like nociception. Schlagwörter: allodynia, animal model, morphine, trigeminal ganglion, trigeminal neuralgia