Purpose: The aim of the study was to compare the mechanical strength of palatal denture bases made from various plastic materials. Materials and Methods: A form and models of an edentulous jaw (Frasaco) were used in the study. The denture bases were made from Zhermacryl H Plus and SR Ivocap Plus (both acrylic resins) and the polyurethane Microbase. Five samples were fabricated for each of the studied polymers. The fracture tests were carried out on a universal testing machine (Hounsfield H5KS). Results: The highest fracture values were assessed on Ivocap specimens. The indicated differences between acrylic resin specimens made of Ivocap and Zhermacryl were not statistically significant. In turn, the differences shown between 2 acrylic resin palatal denture bases and the Microbase were statistically significant (P .05). Conclusion: In this study, samples made from an alternative denture base polymer showed poorer mechanical strength as compared with those made of polymethylmethacrylate.