Purpose: Misfit in the conical implant-abutment interface plays an important role on the mechanical behavior of the implant when masticatory forces are applied. The origin of the misfit adopted in this work is a conical angle difference between implant and abutment, which can be due to a combination of design decisions and manufacturing tolerances. The goal of this work was to investigate the effects of the implant-abutment conical angle difference in the following mechanical features: interfacial microgap, preload loss on the bolt, stress level in the bone, and abutment removal force and/or torque. Materials and Methods: A simplified three-dimensional nonlinear monoparametric finite element model of an OsseoSpeed TX 4.5 S 9-mm implant (Astra Tech) with a tapered implant-abutment interface was built to evaluate the variability of the mechanical features cited above with the conical angle difference, keeping constant the overall geometry, load and boundary conditions, material properties, frictional behavior, and mesh structure. Results: As the conical angle difference increased, the following effects were observed: the microgap decreased and remained almost constant for values over a given positive angle difference, the stress level in the bone increased sensitively, the removal force and/or torque needed to separate the abutment from the implant varied slightly, and the bolt preload loss increased. Conclusions: In light of the results provided, the conical angle difference in the implant-abutment interface had a significant influence on the overall mechanical behavior of the implant. Among the four mechanical features considered, the interfacial microgap and the bone stress were demonstrated to be the most sensitive to the conical angle difference, and therefore the most relevant when selecting an optimum value in the design process of a conical interface.