The aim of this in-vivo study is to evaluate the peri-implant mucosal response to different attachment systems in implant-retained overdentures through clinical examinations. All participants in this study are completely edentulous patients and have received a novel complete maxillary and mandibular dentures. Each patient received two dental implants in the canine area of the mandible. The patients were divided randomly into two equal groups (Group I) Mandibular overdentures were retained to the implants with Novaloc attachments. (Group II) Mandibular overdentures were retained to the implants with Locator attachments. peri-implant mucosal response was clinically evaluated using probing depth (PD), plaque index (PI) and bleeding on probing (BOP). Evaluations were performed (0, 4, 8 and 12) months after implants loading. Statistical comparison of the two groups showed that Group II consistently. experienced. This peer-reviewed, accepted manuscript will undergo final editing and production prior to print publication. Any blinded information will be available then an increase in PD. There was no statistically significant difference between the two groups in BOP and PI over time, although Group II had higher mean values. Based on the findings of this study, Novaloc attachments may have a superior impact on peri-implant soft tissue conditions and mucositis compared to Locator attachments after one year of follow up, potentially leading to improved long-term implant success.