Ectodermal dysplasia (ED) is one of the congenitally syndromic diseases with dental anomalies. This syndrome manifests in various forms and usually requires early restorative therapy to restore esthetics and function in young patients. The restorative approaches vary greatly and range from minimally invasive shape corrections using composite build-ups and removable partial or complete dental prostheses, to implantologic solutions, always based on the syndromic expression, the age of the patient, the residual growth, as well as the dentition itself. The present case report presents an innovative prosthetic management of a young patient suffering from ED with permanent tooth aplasia and persistent primary teeth using maxillomandibular individually veneered tooth-colored CAD/CAM polycarbonate splints. The CAD phase has been significantly improved by including the analysis of 3D face scans. This advanced technical development makes it possible to avoid any time-consuming try-in and start directly with the splint production, ensuring a much faster complete rehabilitation and support for the young patient.