Romanian Cantacuzino Institute produces Staphylococcus vaccine kit D (in dilutions) for the treatment of gingivitis and periodontitis since 1997. The vaccine is 1st generation type and contains 15 strains of staphylococcus. The premise of the method was the presence of the Staphylococcus in the periodontal pocket and its morphophysiological characteristics. D Staphylococcus vaccine kit consists of four boxes of vaccine in different dilutions as follows: 1. Five ampoules of 1 ml of staphylococcus vaccine in the dilution of 106 bacterial parts / 1 ml 2. Five ampoules of 1 ml staphylococcus vaccine in the dilution of 107 bacterial parts / 1ml 3. Five ampoules of 1 ml staphylococcus vaccine in the dilution of 108 bacterial parts / 1ml 4. 10 ampoules of 1ml of concentrated staphylococcus vaccine 109 bacterial parts / 1 ml Administration of the vaccine is 15-18 subcutaneous injections every 1-3 days after the original scheme, combined with a polivaccin (Polidin, product of Cantacuzino Institute) and antibiotics (ampicillin and metronidazole), along with traditional conventional treatment for gingivitis or periodontitis. Reimmunization: at 6 months, 1 year and 2 years time. IDR with dilution of 107 will be performed in patients suspected of allergic reactions. Results: positive evaluation of treatment is assessed by the following signs: - Decrease till absence of gingival inflammation, bleeding and pocket abscess, - Consistency, color and texture of gum is normalized, - Decrease of mobility and loss of sensation of unstable occlusion, - The histological decrease of leucocitary infiltrate and recovery of the depolimerized collagen network. In conclusion, immunotherapy with staphylococcus vaccine by modulating the immune response is an effective mean of treatment of periodontal diseases with predictable and immediate results for the patient. Keywords: periodontal disease, pathogenic agent, microflora of pockets, immunotherapy, modelation of immunity, Staphylococal polyvaccine