Objectives: The study was performed to compare tensile bond strength obtained between composite and bone and between bone and bone using two different adhesive systems (Clearfil New Bond and Histoacryl) in vitro. Methods: Six mandibles of freshly sacrificed pigs were used to prepare ten specimens each using trephane burs under constant water cooling. Sixty bone specimens with a total thickness of 4.0 mm (± 0.5 mm) and a cortical layer of 1.5 mm (± 0.2 mm) were obtained under standardized conditions. Each ten specimens were assigned to four experimental groups (Group A: Clearfil New Bond (bone-composite); Group B: Clearfil New Bond (bone-bone); Group C: Histoacryl (bone-composite); Group D: Histoacryl (bone-bone)). Tensile bond strength of the above mentioned adhesive agents was measured 15 minutes after application and additional after light curing of the composite material (Tetric Ceram, colour A2; Group A,C) using an universal testing machine. Results: Following tensile bond strength were evaluated (mean value and standard deviation, printed in MPa): Group A: 8.00 (± 1.36); Group B: 6.39 (± 2.05); Group C: 5.22 (± 2.01); Group D: 1.95 (± 0.49). Statistical analysis showed a significant influence of the used adhesive system and the modality on tensile bond strength (p Conclusions: Regarding the limitations of an in vitro investigation, it can be concluded that adhesive systems might be a useful alternative in bone bonding. The use of dentin adhesives seemed to produce higher bond strength to bone compared to the cyanoacrylate adhesive. Keywords: bond strength, adhesive systems