DOI: 10.11607/prd.3980, PubMed ID (PMID): 30986287Pages 371-379, Language: EnglishTeng, Fei / Zheng, Yuanna / Wu, Gang / Beekmans, Bart / Wismeijer, Daniel / Lin, Xingnan / Liu, YuelianThis study aimed to histologically investigate the bone tissue response to zirconia implants functionalized with a biomimetic calcium phosphate (CaP) coating incorporated with bone morphogenetic protein-2 (BMP-2). Zirconia implants coated with biomimetic CaP were prepared with and without BMP-2. Untreated zirconia implants served as a control. These three groups of implants were placed randomly in the mandibles of six beagle dogs (n = 6). Three months later, samples were harvested for histomorphometric analysis. The present study showed that the application of a biomimetic CaP coating incorporated with BMP-2 enhanced the peri-implant osteogenesis for zirconia implants.
