A digital smile diagnosis based on Digital Smile Design (DSD) concepts reinforces the predictability and precision of orthodontic and multidisciplinary cases as it allows more accurate planning from an esthetic point of view. The intention of this clinical case series was to verify the relationship between the ideal and adapted smile in three orthodontic multidisciplinary cases treated using the Invisalign system in order to have a better understanding of the correlation between the several smile components. The ideal smile construction requires face, lips, gingival tissue, and tooth analysis and evaluation, as well as the appreciation of how all these aspects occur together. When the ideal smile line is not achievable in difficult clinical situations, the treatment goal would be an adaptation to the same line that supports a more predictable movement range. These DSD and orthodontic concepts should be primarily applied, since all intermediate involvement, as well as the final outcomes, are essentially planned from the beginning in clear aligner treatments. The presented case series allowed the authors to understand the importance of these digital diagnostic tools in dealing with certain particularities in orthodontic clear aligner treatments, both at the beginning and during the refinement/finishing stages.