This case report describes the full-mouth oral rehabilitation of a titanium allergic patient. The patient was a young female with amelogenesis imperfecta who had generalized massive tooth destruction. All teeth in the mouth were extracted and 15 CeraRoot acid-etched (ICE surface®) implants were placed (seven implants in the maxilla and eight implants in the mandible). No immediate temporaries were placed. Temporaries were placed 3 months after surgery, and left in function for 2 months. The case was finally restored with zirconium oxide bridges and ceramic veneering (three bridges in the maxilla and another three in the mandible). The 3-year follow-up showed good stability of soft tissues and bone level. Zirconium oxide implants and restorations might be an alternative for the oral rehabilitation of titanium allergic patients.