Bone marrow transplantation is used with increasing frequency to treat various hematologic diseases, particularly the leukemias. A case involving dental implant therapy in a woman who had undergone successful allogeneic bone marrow transplantation for treatment of chronic myelogenous leukemia is presented to illustrate specific considerations in treatment planning, surgical management, and overall prosthetic rehabilitation. Five mandibular endosseous implants were placed in November 1991 and subsequently restored with a fixed detachable prosthesis. The patient experienced no complications related to the implants or prosthesis during the 3 years after restoration. Keywords: bone marrow transplantation, dental implants, graft-versus-host disease, leukemia