A new endosseous titanium implant has been designed to replace skin adhesives as a method of retention of maxillofacial prostheses. The effects of various methods of preimplantation preparation on surface characteristics of the implant were analyzed with electron spectroscopy for chemical analysis. Having undergone one of several pretreatment protocols, fixtures were implanted in the crania of Yucatan miniature hairless swine. Both argon radiofrequency glow discharge and ultraviolet chamber treated implants were associated with the rapid ingrowth and maturation of new bone around the fixture. Conventional steam sterilization was associated with a paucity of neo-osteogenesis accompanied by the production of thick collagen slings at the interface. Apparently, the bulk material, fixture design, and method of surface preparation all contribute to the ultimate clinical fate of an implant. Keywords: endosseous titanium implant, radiofrequency glow discharge, ultraviolet