Objective: This study investigated the cervical microleakage between a cobalt-chromium (Co-Cr) alloy and four indirect polymeric veneering materials using different adhesive systems. Method and materials: The Co-Cr-based alloy for fixed prosthesis used in this study (Biosil F, Degussa) was veneered with four different polymeric materials: Artglass, Chromasit, Solidex, and Superacryl. Results: Superacryl produced the highest microleakage score (4 ± 0.0). The least microleakage at the interface was produced by Artglass (1 ± 0.816), followed by Chromasit (2 ± 1.414) and Solidex (2.5 ± 1.0). Only the differences between Artglass and Superacryl were significant. Conclusion: Within the limitations of this in vitro study, cervical microleakage between the coping and the veneer depended on the particular polymeric material used for veneering. Leakage was significantly lower when resin materials were used together with a chemical conditioning system (ie, Artglass/Siloc).