Purpose: To examine the alterations in oral healthcare indicators subsequent to the administration of cetylpyridinium chloride.
Materials and Methods: In this retrospective study, clinical data of 58 patients who received orthodontic treatment using removable appliances at our medical facility were collected. Patients were divided into two groups based on whether they used cetylpyridinium chloride during orthodontic treatment: the combined group (n = 31, received 0.1% cetylpyridinium chloride gargle in addition to periodontal cleaning during the use of orthodontic appliances, with gargling applied three times daily for at least 1 min after meals) and the cleaning group (n = 27, received only periodontal cleaning). Data on oral healthcare were collected and analysed at 1, 3, and 6 months into the treatment regimen. The indices evaluated were gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), and plaque index (PLI).
Results: Subsequent evaluations revealed that, at 3 and 6 months post-intervention, patients in the intervention group exhibited statistically lower scores in GI, SBI, and PLI when compared to the control group. Similarly, the PD measurements showed more statistically significant reductions at each follow-up interval — 1, 3, and 6 months — in the intervention group. IL-10 levels were notably higher in the intervention group at 6 months.
Conclusion: Integrating cetylpyridinium chloride into the oral healthcare regimen for patients using removable orthodontic appliances has been shown to statistically significantly improve oral health, enhance periodontal functions, and reduce inflammatory responses in the gingival sulcus.
Keywords: cetylpyridinium chloride, inflammatory cytokines, oral healthcare, removable orthodontic appliance
