Partial fixed dental prostheses supported by dental implants have become a reliable long-term treatment option. Nevertheless, the replacement of two adjacent missing teeth, irrespective of location, still represents a clinical challenge. To overcome this, the use of fixed dental prostheses with cantilever extensions has gained popularity with a view to limiting morbidity, reducing costs and avoiding major surgical interventions prior to implant placement. The present review summarises the level of evidence for the use of fixed dental prostheses with cantilever extensions both in the posterior and anterior regions and indicates the advantages and disadvantages of each treatment, focusing on available medium- to long-term outcomes.